6 - حمض الأمينوبينيسيليك المضادات الحيوية 551-16-6

6-Aminopenicillanic acid (6-APA)

Chemical Data

CAS No

551-16-6

Synonyms

6-APA; aminopenicillanic acid;

6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;

 (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Molecular Formular

C₈H₁₂N₂O₃S

Molecula Weight

216.2575

EINECS NO

208-993-4

Appearance

white or almost white crystalline powder.

Physical property

Density: 1.52 g/mL at 20 °C

melting point: 197-203℃

Boiling point:460.2°C at 760 mmHg

Flashing point: 232.1°C

Vapour pressure:9.54E-10mmHg at 25°C

Packing

25kg net in bag /drum

Uses

Used as pharmaceutical intermediates

Storage

Keep in sealed and damp proof place.

Specification

Appearance

white or almost white crystalline powder.

Specific rotation

+265.0 -- + 285.0°

Identification

A:Infrared absorption spectrum

B:The retention time(HPLC)

Comparing with the spectrum obtained with 6-aminopenicillanic acid CRS:Conform

Corresponds to standard preparation :conforms

PH

3.5-4.0

Loss on drying

≤0.20%

Absorbance at 425nm

≤0.025

Transmittance at 500nm

≥90.0%

Assay

≥96.0%

Penicillin G K

≤0.1%

Phenylacetic acid

≤0.1%

Conclusion

Conform to IN-HOUSE standard